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Many of the metabolic aberrations in IBM muscle tissue converge on the TCA cycle, which is central to producing NADH for the mitochondrial respiratory chain as well as providing metabolic precursors and intermediates for many other key metabolic processes of the cell 27
Additionally, the promoter of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1/PPARG) has two AREs, although they have not been validated as functional, and has been reported to be both up- and downregulated by NRF2 activation depending on the context (OBrien et al., 2015)
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597 In addition, bioinformatics analysis shows that Nrf2 is the target of FTO, and FTO impairs Nrf2 mRNA stability through an m6A dependent pathway, revealing the potential function of FTO in PD neurological diseases
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