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In the ischemia/reperfusion-induced fibrosis C57BL/6J mouse model, transcriptomic and metabolomic analyses showed that dapagliflozin treatment mitigated accumulation of tricarboxylic acid (TCA) circulating metabolites and up-regulation of inflammation in fibrotic renal cortical tissue
The half-life of 159 to 195 hours means there is some flexibility, a day early or late will not ruin the protocol, but regular weekly timing produces the most stable plasma levels
