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Although GlyT1 and GlyT2 share approximately 50% sequence identity, they exhibit distinct pharmacological properties and tissue distributions
3), including H-bonds with the backbone of S129 ECD , and hydrophobic interactions with D77 ECD , G78 ECD , W79 ECD , Y131 ECD and W128 ECD , consistent with interactions also formed by Pro32 of sCT
The dopamine receptor DRD2 has been identified as a novel therapeutic target to remodel the immunosuppressive tumour microenvironment by promoting M1 macrophage polarisation, inhibiting the NF-B signalling pathway, and inducing pyroptosis in breast cancer cells [62], which provides a promising new treatment direction for breast cancer
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J Neurosci 14(5 Pt 1):26972707 Melo IS, Santos YMO, Costa MA et al (2016) Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus [J]
