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However, it is worth nothing that although Kras mutation is not significantly induced by smoking in the pancreas, recent data indicate that nicotine further stimulates mutated Kras activation leading to more aggressive pancreatic tumors in animal models of the disease (50)

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Furthermore, quitting smoking can help manage stress and anxiety levels, further reducing the risk of jaw clenching or teeth grinding

Jeger, Oskar (1980)

The regulation is set out in Decree 371, issued by the government and effective from December 31, 2025