Stop use if rash or irritation develops and lasts
In a mouse model of UUO, treatment with finerenone (3 or 10 mg/kg) once daily starting with the first dose 2 days before UUO, decreased pathological myofibroblast accumulation and collagen deposition along with decreased expression of kidney fibrosis markers PAI-1 and naked cuticle 2 (NKD2) [197]
Nori M, Iwata S, Munakata Y, Kobayashi H, Kobayashi S, Umezawa Y, Hosono O, Kawasaki H, Dang NH, Tanaka H, Shiohara T, Morimoto C (2003) Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines
Funding Open access funding provided by University of Innsbruck and Medical University of Innsbruck
If receptor responsiveness to agonists is rapidly reduced, within, say, a few minutes, it is usually called desensitization