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Lysyl oxidase, the copper-dependent enzyme that catalyzes the oxidative deamination of lysine residues in collagen and elastin (a step required for the cross-linking that gives mature collagen and elastin their mechanical properties), requires copper as a cofactor

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One study in 56 patients with open-angle glaucoma found that such topically applied citicoline for four months improved retinal function and visual-related neural conduction when on top of -blocker monotherapy to lower intraocular pressure (90)