Using SCLC NCI-H69 cells with and without HGF stimulation as the model, the screening arrays KPSS-1.3 and KPSS-2.0 together allowed detection of strong HGF-induction of specific phosphorylation sites in phosphoproteins downstream of c-MET itself, that are involved in diverse cellular regulation, including transcriptional control, cell cycle G 1 /S checkpoint, cell survival and apoptosis, cell proliferation and differentiation, stress and inflammatory response to cytokines and growth factors, as well as cytoskeletal functions
All peptides supplied by Alixa Pharma are intended strictly for laboratory research purposes only and are not for human consumption, medical, or veterinary use
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