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Zanidatamab (formerly ZW25) was constructed using the IgG1-like heterodimeric Azymetric Fc platform, with an anti-HER2-ECD4 single chain variable fragment (scFv) linked to heavy chain 1 and an anti-HER2-ECD2 fragment antigen-binding (Fab) domain on heavy chain 2

However, urine output is not a very reliable index in patients who are taking medication or are perioperative, and other commonly used surrogate indices, such as the serum creatinine concentration, creatinine clearance, or GFR, can only show that AKI and functional impairment is already present, rather than being predictors of their development at an early stage (113)

They have been shown to have the same potency as the well-known hair loss medication minoxidil, but without the severe adverse effects of scalp burning or abrupt facial hair growth

Ellis CE

showed that GC-treated macrophages had a higher capacity to bind and internalize Hb-Hp complex due to CD163 upregulation