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Dysregulation of these pathways contributes profoundly to autoimmune pathogenesis by impairing the clearance of damaged organelles and intracellular debris, promoting chronic inflammation, and sustaining autoreactive immune responses

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NCs are usually found in clusters and secrete matrix rich in proteoglycan and collagen type II [2]

The split-dosing approach (3x weekly vs once weekly) is described as maintaining more consistent hormone levels and reducing peak-related side effects

The issue is proceeding without a clear clinical framework for sequencing, inflammation control, and tissue readiness