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Participants with OCD showed significantly higher levels of Glu (independent sample t -test(58) = 2.08, p = 0.02, p -FDR = 0.04, Cohens d = 0.53 , 95% CI[0.016, 0.83]), Glu:GABA ratio (MannWhitney U = 618, p = 0.006, p -FDR = 0.02, p 2 = 0.10, 95% CI[0.05, 0.70]), and Glx (independent sample t -test(58) = 2.13, p = 0.02, p -FDR = 0.05, Cohens d = 0.55 , 95% CI[0.03, 1.13]) within the ACC voxel

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GSH was shown to be superior to glutamine and may prove to be of therapeutic value for use in both humans and animals

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Furthermore, RCAN1 (also known as DSCR1 ) participates in abnormal cardiac valvuloseptal formation, as well as the abnormal development of several organ systems affected in individuals with DS, including the heart, brain, eyes, ears, face, and limbs (Lange et al., 2004)