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10.1016/j.jnutbio.2020.108479 106

Figure 2 Interestingly, many of the initial studies elucidating NRF2-ARE-mediated cellular protection utilized tert -butyl hydroquinone (tBHQ), a synthetic antioxidant and inducer of the NRF2 pathway via its auto-oxidized, electrophilic form tert-butyl benzoquinone (tBQ) (Rushmore and Pickett, 1990

prolonged splenic exposure (erythrostasis), depletion of red cell glucose, and diminished red cell pH have all been suggested to contribute to these abnormalities ( Fig