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Data analysis Item reduction and internal construct validity: Assessed through the application of the RMT analyses 71 aiming at comparing observed data against the stringent criteria of the Rasch model (see Supplementary Table S3 for more details on the definition and acceptability criteria for RMT analysis)

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Whole saliva samples (2 ml) were collected by spitting into a SalivaGene Collector (Stratech Molecular GmbH, Germany) containing lyophilized DNA stabilization buffer, according to the instructions of the manufacturer

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