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The rate of major bleeding on apixaban in real-world registries ranges from 1.5% to 3.5% per patient-year, depending on patient age, renal function, and concomitant medications [15]

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Abd Hamid IA, Ismail N, Abd Rahman N

First, translations of animal study data, then long-standing patterns established by experimental usage and mentioned in forums and lastly, specific protocols used by clinics and compounding pharmacies