Kim et al., 2006
In rabbit models, intra-articular injection of scAAV2 encoding interleukin-1 receptor antagonist (IL-1Ra) yielded sustained therapeutic protein expression in both inflamed and normal joints for at least two weeks, with minimal immune activation or joint pathology (178)
doi: 10.1126/science.adh8488
Eur J Pediatr 169:12011206 Chauhan V, Chauhan A, Cohen IL, Brown WT, Sheikh A (2004) Alteration in amino-glycerophospholipids levels in the plasma of children with autism: a potential biochemical diagnostic marker
High alcohol consumption activates microglia and dramatically increases ROS production (Qin and Crews, 2012), which can, in extreme situations, affect the fluidity of the mitochondrial membrane, resulting in functional changes and an increase in oxidant production (Lucchini et al., 2012)