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Given the rapid aura onset following CGRP infusion, it is challenging to argue that spontaneous migraine aura coincidentally occurred during this period

Acknowledgments We thank Editage (www.editage.cn) for its linguistic assistance during the preparation of this manuscript

Other reasons for hyper-vascularization are UV-induced solar elastosis and elevation of cytokines such as stem cell factor (SCF), inducible nitric oxide synthase (iNOS), and c-KIT (a strong melanogenic cytokine) (Kang et al., 2006