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They required a delivery system that could carry glutathione past the stratum corneum to reach dermal fibroblasts, a feat impossible for standard formulations

Although altered specificity in the GS reaction mechanism offers a direct route to analog synthesis, it is possible that other enzymes catalyze additional reactions that modify glutathione into the specialized peptides, like hydroxymethylglutathione

Stefan N, Staiger H, Haring HU (2011) Dissociation between fatty liver and insulin resistance: the role of adipose triacylglycerol lipase

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However, just like any other cosmetic procedure, glutathione can cause unfavourable side effects