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In a rat model of hyperthyroidism induced by levothyroxine sodium, total extract and large polar iridoid fractions of Scrophulariae Radix significantly decrease key enzymes involved in glycolysis and the tricarboxylic acid cycle under hypermetabolic conditions (103)

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GSH, however, is rapidly hydrolysed by the hepatic enzyme -glutamyl transferase (GGT), which, in addition to the biological barriers of the GIT, accounts for its low oral bioavailability [18]

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In this scheme, both executive and threat/arousal circuits are functioning normally at the biological level, but their feedback interactions produce a vicious cycle of anxiety and distorted cognitions