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Further supporting melatonins potential impact on brain insulin, a rat study demonstrated that melatonin, upon binding to its membrane-bound receptors, can initiate intracellular pathways in the brain typically activated by insulin binding to the insulin receptor (e.g., AKT serine phosphorylation) [137]

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Alternatively, low-level oxidative stress is known to activate different protein cascades and transcription factors, such as AP-1, HIF-1, and NF-B [2, 3, 1618, 26, 5155]

The body produces it in the liver, kidneys, and pancreas