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Although MAPT mutations are not specifically associated with AD, tau tangles are a key hallmark of the disease, and in humans the number of neurofibrillary tangles correlates with cognitive decline and neurodegeneration better than A plaques (Giannakopoulos et al., 2003)

Development of predictive biomarkers and improved formulations would also advance clinical applications

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If you accidentally freeze a vial, discard it

This process could shift the fibrotic response from pathological persistent collagen deposition to physiological collagen contraction