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Through attenuation of chronic hypothalamicpituitaryadrenal (HPA) axis overactivation, adaptogens such as Withania somnifera can normalize thyrotropin-releasing hormone (TRH) and thyroid-stimulating hormone (TSH) signaling, thereby improving peripheral thyroid hormone bioavailability (186)

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doi: 10.1186/s12986-019-0410-3 55 XuYHuangXHuangfuBHuYXuJGaoRet al

In murine models of diet-induced MASH, loss of CD8 + T cell-derived perforin exacerbates liver injury and promotes the expansion of proinflammatory monocytes and overactivation of hepatic CD8 + T cells (143)

Researchers combine these peptides to evaluate potential synergistic interactions across overlapping molecular pathways in preclinical assay systems