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[109] Melatonin is also known to modify many cytokines, including TNF, IL1, IL-2, IL-6, and gamma-interferon, in ways consistent with increased host defense against cancers

While age and sex cannot be modified, knee OA is strongly associated with lifestyle factors that can be controlled

Subgroup analysis based on the country showed that the improving effects of NAC on the endometrial thickness are more significant in some countries

however, these differences were not statistically significant (Fig