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The most commonly reported adverse events were mild-to-moderate headache and gastrointestinal effects including flatulence and mild diarrhea

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This angiogenic activity is believed to underlie a substantial part of the compounds regenerative behaviour in laboratory work, since improved vascular supply supports the delivery of nutrients to repairing tissue

Overdoing it can occasionally lead to side effects like nerve irritation (with too much B6), skin flushing (from high-dose B3), or digestive upset