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For instance, two siblings both harboring the same mitochondrial mutation causing Lebers hereditary optic neuropathy had markedly different clinical courses: the brother exhibited typical progressive optic neuropathy whereas the sister suffered from a relapsingremitting MS-like illness (Joshi and Kermode, 2019)

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Second, it activates the FAK-paxillin signalling pathway, which drives fibroblast migration, survival under oxidative stress, and outgrowth from tendon explants