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As noted above, Trxs are responsible for reducing Prx back to their reduced, oxidant-scavenging state, while thioredoxin reductases (TrxRDs) keep the reduced state of Trxs using NAPDH reducing equivalents, as depicted in Figure 2

Discussion Gout is a prevalent disease resulting from the accumulation of MSU crystals in joints or soft tissues, typically presenting as rapid-onset acute monoarthritis with symptoms such as intense joint pain, erythema, increased local temperature, swelling, and functional impairment [56]

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The chemical structure of glutathione contains three types of amino acids, among which glutamic acid and cysteine are in the L-type configuration, which is the common form of amino acids in proteins in nature

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