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J., Robinette, M

NAPQI Formation Highest in FIRST Trimester 43% HIGHER The same Brookhuis 2021 study found: The estimated molar dose fraction of NAPQI was the highest in the first trimester (median (IQR): 11 (9.113.4%), followed by the second (9.0 (7.511%)) and third (8.2 (6.810.1)) trimester compared with non-pregnant women (7.7 (6.49.4%)).[] **This represents a 43% INCREASE in toxic NAPQI formation in the first trimester** (11% vs 7.7%)precisely when the fetal brain is most vulnerable and undergoing critical early development

This is a great example of how a preventative approach nowcan save a lot of trouble later

These metabolites are derived from various metabolic pathways and have diverse functions that range from proteogenic amino acids (Cys, Met), hormone derivatives (e.g., sulfojasmonate and sulfated brassinosteroids), antioxidants (e.g., GSH), signaling molecules (phosphonucleotide, PAP, and H 2 S), and secondary metabolites (GSLs, sulfoflavonoids)

Chemistry & Biodiversity 4: 1649-1663