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Single immune checkpoint inhibitors (sICIs) are frequently reported to cause adverse events (AEs) such as rash, jaundice, hypothyroidism, pneumonitis, neutropenia, and in some cases, necessitate medication discontinuation ( Although dICIs are currently approved for various cancer indications and have demonstrated superior efficacy compared to sICI therapy, their safety profile and limitations warrant careful consideration ( Materials and methods Data source The original data utilized for our data mining were sourced exclusively from the FAERS database available on the official FDA website

Members of the families Turicibacteraceae , Erysipelotrichaceae , and Desulfobirionaceae were identified to be altered in the large intestine upon H

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Research protocols vary depending on study goals and application