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Over time, your brain adapts by down-regulating its own natural production and sensitivity to these chemicals, requiring you to consume more of the stimulant just to reach your normal baseline

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Nevertheless, cystine is taken up by some cells (i.e., endothelial cells) and, given the high reducing conditions, is intracellularly reduced to cysteine, employed for the synthesis of GSH (10, 11)

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1 2 The Cochrane Database of Systematic Reviews (1) CD002081