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Hypothyroid animals also have prolonged wound healing due to increased mast cells.[ref][ref][ref] Related article: Thyroid hormones, genetics, and hypothyroidism Asthma and mast cell activation: Mast cells are abundant near the epithelial cells lining the lungs

Nevertheless, human clinical trials remain extremely limited

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In fact, most of the patients with TDP-43 pathology do not have mutations in their TARDP gene, and yet have protein accumulations containing phosphorylated TDP-43 13 , and mostly ubiquitinated protein aggregates 10,14,15